Personalise diet, fertility and medication with genetic testing

Body basics For most of people, working out the exercise and diet best suited to them is a guessing game.

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Same same, but different

Biochemical pharmacologist, Professor Collen Masimirembwa, suggests a closer look at human genetics might be one way to improve ARV therapy.

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Genetics… the future of healthcare and medicine

Essentially, genetic testing and screening is used as a tool to detect the gene variants associated with a specific disease

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Polygenic risk scores can identify patients who will benefit most from statin therapy

The question is if it can be shown that there is a specific subgroup of patients that may benefit more

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A Brave new world of genetic diagnosis and medicine

We now live in era of unparalleled knowledge of the molecular details of disease and this has led to powerful

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Vitamin B12 Deficiency Indicators

B12 is essential for the metabolism of all human cells and is required for two key reactions: MUT reaction: energy

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Safety, efficacy of Biosimilar human insulins

Estimates from 2015 by the International Diabetes Federation suggest that the number of adults with diabetes in the world will

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Take it till you make it

According to the authors, “Rheumatoid arthritis (RA) is a systemic, inflammatory condition that can affect multiple organs, but which is

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Not so hot

“Patients with GORD may also experience significant complications associated with the disease, such as oesophagitis, stricture, and Barrett oesophagus. Approximately

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The Role of Vit D and Zinc in BP control

Approximately 13% of deaths overall are caused by high blood pressure, while 40% of deaths in people with diabetes are

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Getting a grip on Gastroenteritis

Diarrhoea is a common problem that can affect anyone at any age. Causes Viruses The viruses most commonly implicated are

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Achieving glycaemic control

“This alarming rate of increase in incidence together with the potential complications of disease renders this disease to be a

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Postoperative pain: a psychological assessement

An effective postoperative management is not a standardised regime and is rather tailored to the needs of the individual patient,

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The treatment of asthma

Implementing treatment for chronic asthma Avoidance of triggers, wherever possible, helps to minimise asthma severity and reduces asthma exacerbations. This

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Management of conjunctivitis

Conjunctivitis has a number of different causes, including: Viruses Bacteria Irritants such as shampoos, dirt, smoke, and pool chlorine Allergiens

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A new era in the management of type 2 Diabetes

Globally, the obesity and diabetes pandemics are driving the increase in macrovascular complications, with ischaemic heart disease and stroke the

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Hyluronans and Molecilar weight

However, it has become clear that mechanisms of action for osteoarthritis pain management are not only mechanical but also biological.

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Review of once-monthly oral ibandronate

Risedronate (5mg daily) – The Vertebral Efficacy with Risedronate Therapy (VERT-NA and VERT-International) studies which demonstrated vertebral fracture efficacy. The

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Sanofi launches new once-daily oral treatment for RRMS

Since 2005, ten clinical trials involving more than 4000 patients have been conducted. Since then, Aubagio has been approved for

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Codeine Care Initiative

In the performance of its duties, the MCC applies the guidelines set out by the Medicines and Related Substances Act,

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PAIN: A sensory and emotional experience

They can be divided into two main groups which describe the presenting symptoms (although these can overlap and one may

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Antihistamine that tackles inflammation

Histamine is clearly not the only mediator involved in the inflammatory process. There is an emerging view that drugs that

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Surviving the rollercoaster: adult ADHD

Drs Renata Schoeman and Rykie Liebenberg of the South African Society of Psychiatrists (SASOP) Special Interest Group (SIG) for adult

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OST reduces risk of HIV infection

Cohen et al showed that the introduction of early antiretroviral therapy (ART) was associated with a 97% lower risk of

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Burning Issue

At its best, this is a self-contained interdisciplinary environment with dedicated, isolated beds, sub-specialist surgeons, supported by an interdisciplinary team

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Vitamin B deficiencies and treatment

Vitamins are organic compounds that are essential for normal physiological functions and the maintenance of optimal health. They cannot be

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Sun protection

Fifty percent of solar radiation is Infrared in the form of heat energy and is perceived as warmth.  Even a single

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Multiple MoA

Allergic conjunctivitis is caused by airborne allergens contacting the eye, which leads to immunoglobulin E (IgE)-mediated local mast cell degranulation

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Hot and bothered

“Treatment should be individualised to identify the most appropriate HT type, dose, formulation, route of administration, and duration of use,

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Rare but there

Male breast cancer accounts for only 0.7% of all breast cancer diagnoses. The mean age at diagnosis for men with

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How effective is the LNG-IUS in relieving chronic pelvic pain caused by AM?

The definition of AM is characterised by the presence of heterotopic endometrial glands and stroma within the myometrium, >2.5mm in

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Women’s hearts

Premature deaths caused by heart and blood vessel diseases (CVD) in people of working age (35-64 years) are expected to

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Clinical Update: Erectile Dysfunction

Peripherally acting agents Oral phosphodiesterase-5 (PDE-5) inhibitors The PDE-5 inhibitors remain the first choice therapy in most patients with erectile

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Managing a monster

It is not surprising that 415 million people are estimated to have diabetes in the world and WHO predicts that

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Risk of sudden death in heart failure

Current recommended treatment for heart failure: Angiotensin-converting enzyme inhibitor (ACE-Inhibitors) or Angiotensin-receptor blockers (ARB), beta-blockers (Carvedilol, Bisoprolol and Metoprolol) and

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Vaginal infections: An overview

Three common infections are associated with vaginal discharge: Bacterial vaginosis (BV), trichomoniasis and candidiasis, of which trichomoniasis is a sexually

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Issues in hypertension

Hypertension increases the risk for coronary heart disease by two-fold and the risk for heart failure and stroke by four-fold.

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What is the impact on CVD outcome of non-adherence?

Prof. James Ker, Senior Lecturer, Department of Internal Medicine, University of Pretoria As measured over the last two decades, the

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Heart failure with preserved ejection fraction

Heart failure with reduced ejection fraction has shown improved outcomes with evidence-based treatment but heart failure with preserved ejection fraction

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A first for SA

Spec Etoricoxib is indicated for the acute use for short-term relief of acute gouty arthritis, acute pain, primary dysmenorrhea and

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Issues in hypertension

Hypertension increases the risk for coronary heart disease by two-fold and the risk for heart failure and stroke by four-fold.

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Stable angina pectoris

Basic concept Ischaemic heart disease refers to a state in which there is inadequate blood supply (oxygen) to a portion

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RTIs linked to asthma

An international study of 154 492 European children found that those who had had upper respiratory infections, such as colds,

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Advances in IBS

IBS also represents a major burden in terms of patient quality of life, work productivity, and healthcare costs. Considerable advances

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COCs: Impact of oestrogen type on CV safety

As combined oral contraceptives (COCs) have been further developed over the past decades, their ethinylestradiol (EE) content has been reduced.

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Weight gain studied for second-generation antipsychotics

The Cincinnati Children’s Hospital Medical Center study found that patients treated with Zyprexa (olanzapine) have the highest risk of weight

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Cough treatment

These receptors generate information that reaches the central nervous system. The central organisation of cough reflex loop is poorly understood.

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Antibiotics or watchful waiting?

More than 20% of antibiotics prescribed in adults are for sinusitis or rhinosinusitis, making it the fifth most common diagnosis

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Advances in the pharmacological treatment of Irritable Bowel Syndrome

Irritable bowel syndrome (IBS) is a common functional bowel problem that mostly affects younger individuals, mostly women (a 2:1 female

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Gut health

These are usually dealt with symptomatically with drugs that can reduce the discomfort for the patient despite the fact that

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Avoiding litigation: It’s not child’s play

There has been a dramatic increase in medical litigation in recent years. Those practicing in specialties considered high risk such

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Brain-gut axis is real

IBS is defined as chronic abdominal symptoms of bloating, altered bowel habit and cramping pain arising from the colon but

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Adult rhinosinusitis

Rhinosinusitis is a common condition, which affects about 30% of the population at some point. Of this number, about 1% develop

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Battling bacterial conjunctivitis

Bacterial  conjunctivitis is inflammation  of  the  conjunctiva  caused by direct  contact with infected secretions. The most common organisms are Staphylococcus

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Be SMART about diabetes care

According to Distiller et al, who focusses on the SA cohort that forms part of the International Diabetes Management Practice

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Type 2 diabetes: should you be prescribing aspirin therapy?

The 2017 updated SEMDSA guidelines have strongly recommended that aspirin should be prescribed for the secondary prevention of cardiovascular disease

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Pause for thought

The details were published Menopause, the journal of The North American Menopause Society (NAMS). A study of 749 Brazilian women

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A nauseating feeling

Chemotherapy-induced nausea and vomiting (CINV) is associated with a significant deterioration in the quality of life.  In the past two

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Advances in Irritable bowel syndrome (IBS)

Irritable bowel syndrome (IBS) is characterised by chronic intermittent abdominal pain and associated diarrhoea (IBS-D), constipation (IBS-C), or both. IBS

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Managing neovascular AMD

Age-related macular degeneration (AMD) has been described as the leading cause of legal blindness, affecting 10%-13% of adults over 65

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Ocular Allergies: Seasonal allergic conjunctivitis

Although not vision-threatening, seasonal allergic conjunctivitis accounts for a significant amount of patient morbidity, discomfort, and cosmetic concern. The antigens

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Medicinal use of Pelargonium sidoides

Pelargonium sidoides is an important traditional medicine with a rich ethnobotanical history. The importance of Pelargonium species, most notably Pelargonium

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Manifestations of the metabolic syndrome: Part 1

The metabolic syndrome (Met-S) is a concept that has evolved over the past 20 years, describing a complex combination of metabolic,

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Myofascial pain syndrome on the increase

MFTPs are categorised clinically dependent on their type. There are two types of MFTPs – active and latent (Travell and

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Importance of adherence to treatment

The global prevalence of T2DM among adults over 18 years of age has risen from 4.7% in 1980 to 8.5%

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SMART diabetes care

Diabetes has become a leading cause of death worldwide. Although there is no cure for diabetes, blood glucose monitoring combined

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PPIs for NSAIDs induced gastropathy

Nonsteroidal anti-inflammatory drugs (NSAIDs) constitute a well-known group of drugs that are most widely used for a variety of inflammatory

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Burden of HIV-associated Cryptococcal meningitis

Cryptococcus is the most common cause of meningitis in adults living with HIV in sub-Saharan Africa. Estimates of national, regional,

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Basic airway management course

The course was planned and organized by Dr Joyce Baloyi, Dr Noneka Cangas, Dr Grace Machinima and Dr Melody Ledwaba,

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Superficial fungal infections of the nails

Aetiology and prevalence There are many diseases that can afflict the nails causing them to become unsightly. Of those diseases,

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The big bong theory

Cannabis has been around for centuries. It most likely originated in the mountains of Kazakhstan from where it spread via

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Clinical and ethical considerations for terminal cancer patients

When decisions arise concerning the treatment of dying patients, these options present complex clinical and ethical dilemmas. Many are faced

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The role of N2O in clinical practice

Minimal sedation and anxiolysis: A drug-induced state during which the patient responds normally to verbal commands.Cognitive function and physical coordination

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Moving IBD care into the 21st century

IBD care is often fragmented, poorly coordinated and determined by forces beyond the control of patients and their doctors. IBD

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Post-stroke pain

Post-stroke pain is common. It remains under diagnosed and undertreated. Post-stroke pain is associated with depression, cognitive dysfunction and an

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SASA regional anaesthesia guideline

Major regional analgesia may be initiated for pain management alone including in labour or in the perioperative setting. In certain

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Rapid access protocol

The findings of their study was presented at the US Association of Academic Physiatrists Annual Meeting hosted in Las Vegas

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Manifestations of the metabolic syndrome: part 2

Focusing in on certain core aspects of this complex pathophysiology, Prof R DeFronzo stated that there are eight factors that

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Enhancement of fluoxetine by folic acid

For this reason, a randomised, double-blind study recently sought to evaluate whether the co-administration of folic acid would enhance the

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The right vitamins for osteoporosis

Osteoporosis is a common disease characterised by low bone strength that results    in an increased risk of fracture. In

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The importance of a balanced immune system

When out of balance, the immune system not only fails to protect the body but can even attack it, mistaking

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Bacterial conjunctivitis: Making every drop count

Conjunctivitis is estimated to contribute 1% of ophthalmic problems or disorders seen in primary care setting, and 1 – 4%

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New agent for a poorly controlled condition

Asthma is common. In SA, it is estimated that 20% of adolescent children have asthma. And, despite the fact that

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