Knee osteoarthritis (OA) is the first cause of chronic functional disabilities in developed countries with about 250 million people in the world suffering from knee OA. Intra-articular administration of hyaluronic acid (IA HA) has been demonstrated to be as effective as non-steroidal anti-inflammatory drugs (NSAIDs) and to induce fewer systemic adverse events.  

IA HA improves viscoelasticity, lubrication and shock absorption properties of the synovial fluid.

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