Obesity continues to be a grave public health concern across the globe. Multiple negative health outcomes associated with obesity have been documented, including an association with type 2 diabetes, high blood pressure, heart disease and strokes, certain types of cancer, sleep apnoea, osteoarthritis, fatty liver disease, kidney disease and pregnancy problems.

Weight loss is difficult for most patients, and the patient's desire to restrict food and energy intake is counteracted by adaptive biological responses to weight loss.

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