In a survey of patients with psoriasis conducted by the American National Psoriasis Foundation, the majority of patients felt that the condition was a problem in their daily life (94%), affected their overall emotional well-being (88%), and interfered with their enjoyment of life (82%). The emotional impact of psoriasis was greater in patients with severe (>10% self-reported body surface area [BSA] involvement) compared with those with mild disease (>3% BSA).

The hallmark of psoriasis is sustained inflammation that leads to uncontrolled keratinocyte proliferation and dysfunctional differentiation.

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