Histamine is released from the granules of mast cells and basophils along with tryptase and other preformed mediators, as well as leukotrienes, prostaglandins, and other newly generated mediators, after the crosslinking of surface IgE by allergen or through mechanisms that are independent of IgE.

Histamine plays a pivotal role in allergic inflammation, which is a complex network of cellular events that involve redundant mediators and signals.

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