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Second-generation antihistamines for chronic spontaneous urticaria

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CSU significantly impairs patients' quality of life due to the severity of its symptoms and associated health issues [Image: Shutterstock].

CSU is characterised by recurring wheals lasting over six weeks, typically initiated by mast cell activity. Mast cells are elevated in the skin of CSU patients, contributing to the condition. CSU predominantly affects females, with a male-to-female ratio of 1.5:1 to 2:1, mirroring patterns seen in autoimmune diseases.

The unpredictable nature of CSU wheals and severe itching often leads to persistent stress, negatively impacting mood and overall quality of life. Depression, anxiety, and sleep disturbances are more prevalent in CSU...

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