Infertility is estimated to affect between 8% and 12% of reproductive-aged couples worldwide. In some regions of the world such as South and Central Asia, the Middle East, sub-Saharan and North Africa as well as Eastern Europe, the rates of infertility are much higher, reaching ∼30%.

Anovulatory infertility, particularly the type due to PCOS, represents one of the major factors responsible for the increasing resort to ovulation induction worldwide.

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