The prevalence of obesity has increased substantially among current generations in Western countries, and the burden of obesity-related complications has been growing steadily, reaching epidemic proportions. Globally, an estimated 2.1 billion adults are classified as overweight or obese and it is likely that changes in lifestyle factors and caloric habits are largely responsible for this course of events. Obesity is a significant risk factor for increased mortality, mainly because of its association with diabetes, cardiovascular disease, cancer, metabolic syndrome, hyperlipidaemia, a proinflammatory state and cancer arising from the severe metabolic alterations caused by excess weight.

Excessive adipose tissue in men suppresses the hypothalamus-pituitary-gonadal axis, leading to a reduction in testosterone levels and associated loss of fertility.

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