Cough is a reflex phenomenon occurring when sensitive receptors located in the larynx and upper airways are activated. These receptors generate information that reaches the central nervous system, although the central organisation of cough reflex loop is poorly understood. The afferent pathways originate in receptors situated under and between airway epithelial cells. Most are rapidly adapting receptors (RAR) linked to myelinated fibres of the vagus nerve, which can be directly stimulated by cough-inducing agents other receptors generate information, carried by...
